Angiotensin II (AT-II)

Definition:

Angiotensin II (AT-II), a product of the renin-angiotensin-aldosterone system, is an alternative potent vasoconstrictor without chronotropic or inotropic properties. AT-II alao is a pro-fibrotic compound that acts via membrane-bound receptors (AT-1R/AT-2R) and thereby activates hepatic stellate cells (HSCs).

References:

[1]. Amar P Jadhav, et al. Angiotensin II in septic shock. Am J Emerg Med. 2019 Jun;37(6):1169-1174. [Content Brief]

[2]. Golnar Karimian, et al. Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis. PLoS One. 2012;7(12):e52647. [Content Brief]

[3]. Nuttha Lumlertgul, et al. Roles of angiotensin II as vasopressor in vasodilatory shock. Future Cardiol. 2020 Nov;16(6):569-583. [Content Brief]

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