Anterior gradient protein 2 homolog

Definition:

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.

References:

[1]. Zheng Wang, et al. The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation. Cancer Res. 2008 Jan 15;68(2):492-7. [Content Brief]

[2]. Pryank Patel, et al. Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion. J Mol Biol. 2013 Mar 11;425(5):929-43. [Content Brief]

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