Arylsulfatase K

Definition:

Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate. Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate.

References:

[1]. Elena Marie Wiegmann, et al. Arylsulfatase K, a novel lysosomal sulfatase. J Biol Chem. 2013 Oct 18;288(42):30019-30028. [Content Brief]

[2]. Omkar P Dhamale, et al. Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase. ACS Chem Biol. 2017 Feb 17;12(2):367-373. [Content Brief]

[3]. Sarah Verheyen, et al. Novel subtype of mucopolysaccharidosis caused by arylsulfatase K (ARSK) deficiency. J Med Genet. 2022 Oct;59(10):957-964. [Content Brief]

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