Band 3 anion transport protein

Definition:

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.; (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes.

References:

[1]. Sandrine Genetet, et al. Stomatin modulates the activity of the Anion Exchanger 1 (AE1, SLC4A1). Sci Rep. 2017 Apr 7;7:46170. [Content Brief]

[2]. A E Schofield, et al. Basis of unique red cell membrane properties in hereditary ovalocytosis. J Mol Biol. 1992 Feb 20;223(4):949-58. [Content Brief]

[3]. Xuerong Li, et al. A co-ligand complex anchors Plasmodium falciparum merozoites to the erythrocyte invasion receptor band 3. J Biol Chem. 2004 Feb 13;279(7):5765-71. [Content Brief]

[4]. Volodymyr Shnitsar, et al. A substrate access tunnel in the cytosolic domain is not an essential feature of the solute carrier 4 (SLC4) family of bicarbonate transporters. J Biol Chem. 2013 Nov 22;288(47):33848-33860. [Content Brief]

[5]. Lesley J Bruce, et al. Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1. Nat Genet. 2005 Nov;37(11):1258-63. [Content Brief]

[6]. L J Bruce, et al. Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells. Biochem J. 2000 Aug 15;350 Pt 1(Pt 1):41-51. [Content Brief]

[7]. Duangporn Ungsupravate, et al. Impaired trafficking and intracellular retention of mutant kidney anion exchanger 1 proteins (G701D and A858D) associated with distal renal tubular acidosis. Mol Membr Biol. 2010 Apr;27(2-3):92-103. [Content Brief]

[8]. Nanyawan Rungroj, et al. A novel missense mutation in AE1 causing autosomal dominant distal renal tubular acidosis retains normal transport function but is mistargeted in polarized epithelial cells. J Biol Chem. 2004 Apr 2;279(14):13833-8. [Content Brief]

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