Band 4.1-like protein 4B

Definition:

Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing. May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation.

References:

[1]. Hiroyuki Nakajima, et al. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. J Cell Biol. 2011 Oct 17;195(2):245-61. [Content Brief]

[2]. Sanjay Chauhan, et al. Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation. Biochem Biophys Res Commun. 2003 Oct 17;310(2):421-32. [Content Brief]

[3]. David C Bosanquet, et al. Expressed in high metastatic cells (Ehm2) is a positive regulator of keratinocyte adhesion and motility: The implication for wound healing. J Dermatol Sci. 2013 Aug;71(2):115-21. [Content Brief]

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