Bax inhibitor 1

Definition:

Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).

References:

[1]. Geert Bultynck, et al. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. J Biol Chem. 2012 Jan 20;287(4):2544-57. [Content Brief]

[2]. Maryla Krajewska, et al. Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury. Brain Res. 2011 Jan 25;1370:227-37. [Content Brief]

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