BEN domain-containing protein 3

Definition:

Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities.

References:

[1]. Ganesha P Pitchai, et al. A novel TPR-BEN domain interaction mediates PICH-BEND3 association. Nucleic Acids Res. 2017 Nov 2;45(19):11413-11424. [Content Brief]

[2]. Kizhakke M Sathyan, et al. A BEN-domain-containing protein associates with heterochromatin and represses transcription. J Cell Sci. 2011 Sep 15;124(Pt 18):3149-63. [Content Brief]

[3]. Abid Khan, et al. BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8338-43. [Content Brief]

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