BolA-like protein 1

Definition:

Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5. May protect cells against oxidative stress.

References:

[1]. Marta A Uzarska, et al. Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins. Elife. 2016 Aug 17;5:e16673. [Content Brief]

[2]. Peter Willems, et al. BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion. Antioxid Redox Signal. 2013 Jan 10;18(2):129-38. [Content Brief]

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