C-C chemokine receptor type 4

Definition:

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

References:

[1]. Ying Wang, et al. Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4). Life Sci. 2006 Jan 2;78(6):614-21. [Content Brief]

[2]. T Imai, et al. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J Biol Chem. 1998 Jan 16;273(3):1764-8. [Content Brief]

[3]. J J Campbell, et al. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature. 1999 Aug 19;400(6746):776-80. [Content Brief]

[4]. T Imai, et al. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J Biol Chem. 1997 Jun 6;272(23):15036-42. [Content Brief]

[5]. M Inngjerdingen, et al. Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. J Immunol. 2000 Apr 15;164(8):4048-54. [Content Brief]

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