C-type lectin domain family 2 member A
Definition:
Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.
References:
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[1]. Eduardo Huarte, et al. PILAR is a novel modulator of human T-cell expansion. Blood. 2008 Aug 15;112(4):1259-68. [Content Brief]
[2]. Jessica Spreu, et al. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5100-5. [Content Brief]
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