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Ca9-22

Definition:

Ca9-22 is a human cancer cell line derived from Oral cavity, gingiva and associated with Gingival squamous cell carcinoma and Squamous cell carcinoma of the oral cavity. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. Ca9-22 is used as an in vitro model of Gingival squamous cell carcinoma and Squamous cell carcinoma of the oral cavity to investigate tumor-cell growth, cell survival, and pharmacological response.

References:

[1]. Hirasawa T, et al. Curcumin pretreatment prevents butyrate-induced cell death and release of damage-associated molecular patterns on gingival epithelial Ca9-22 cells. Journal of oral biosciences. 2025;67(1):100613.

[2]. Fujiwara Y, et al. Reactive oxygen species-dependent release of damage-associated molecular patterns from human gingival epithelial Ca9-22 cells during butyrate or propionate exposure. Journal of oral science. 2021;63(2):195-197.

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