Capping protein-inhibiting regulator of actin dynamics

Definition:

Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin.

References:

[1]. Youn-Sang Jung, et al. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. Nat Cell Biol. 2018 Nov;20(11):1303-1314. [Content Brief]

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