Carcinoembryonic antigen-related cell adhesion molecule 5

Definition

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

References:

[1]. C Ordoñez, et al. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res. 2000 Jul 1;60(13):3419-24. [Content Brief]

[2]. Natalia Korotkova, et al. Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation. Mol Microbiol. 2008 Jan;67(2):420-34. [Content Brief]

[3]. M Taheri, et al. Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion. J Biol Chem. 2000 Sep 1;275(35):26935-43. [Content Brief]

[4]. S Oikawa, et al. Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion. Biochem Biophys Res Commun. 1989 Oct 16;164(1):39-45. [Content Brief]

生物医学辞典

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