Cardiac phospholamban

Definition:

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.

References:

[1]. Delaine K Ceholski, et al. Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A. J Biol Chem. 2012 Aug 3;287(32):26596-605. [Content Brief]

[2]. Delaine K Ceholski, et al. Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy. J Biol Chem. 2012 May 11;287(20):16521-9. [Content Brief]

[3]. Yan G Zhao, et al. The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell. 2017 Sep 21;67(6):974-989.e6. [Content Brief]

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