CCAAT/enhancer-binding protein epsilon

Definition:

Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.

References:

[1]. Taizo Wada, et al. A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency. J Immunol. 2015 Jul 1;195(1):80-6. [Content Brief]

[2]. J A Lekstrom-Himes, et al. Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon. J Exp Med. 1999 Jun 7;189(11):1847-52. [Content Brief]

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