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CCRF-SB

Definition:

CCRF-SB is a human B-cell-derived cancer cell line derived from Peripheral blood and associated with Childhood T acute lymphoblastic leukemia and Precursor T-cell acute lymphoblastic leukemia. CCRF-SB is immortalized or transformed by Epstein-Barr virus (EBV). CCRF-SB is used as an in vitro model of Childhood T acute lymphoblastic leukemia and Precursor T-cell acute lymphoblastic leukemia to investigate apoptosis, cell-cycle control, and cytotoxicity.

Verweise:

[1]. Mendoza-Santiago A, et al. Glutamic Acid Increased Methotrexate Polyglutamation and Cytotoxicity in a CCRF-SB Acute Lymphoblastic Leukemia Cell Line. Medicina (Kaunas, Lithuania). 2019;55(12).

[2]. Skierski JS, Koronkiewicz M, Grieb P. Tezacitabine blocks tumor cells in G1 and S phases of the cell cycle and induces apoptotic cell death. Acta poloniae pharmaceutica. 2005;62(3):195-205. [Content Brief]

Biomedical Dictionary

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