CDC42 small effector protein 2
Definition:
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
References:
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[1]. D M Pirone, et al. SPECs, small binding proteins for Cdc42. J Biol Chem. 2000 Jul 28;275(30):22650-6. [Content Brief]
[2]. Kathryn H Ching, et al. The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse. J Biol Chem. 2005 Jun 24;280(25):23660-7. [Content Brief]
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