Cell surface glycoprotein MUC18

Definition:

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

References:

[1]. F Anfosso, et al. Outside-in signaling pathway linked to CD146 engagement in human endothelial cells. J Biol Chem. 2001 Jan 12;276(2):1564-9. [Content Brief]

[2]. J P Johnson, et al. The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family. Melanoma Res. 1993 Oct;3(5):337-40. [Content Brief]

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