Centromere protein J

Definition:

Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release.

References:

[1]. Julia Kleylein-Sohn, et al. Plk4-induced centriole biogenesis in human cells. Dev Cell. 2007 Aug;13(2):190-202. [Content Brief]

[2]. Ashwani Sharma, et al. Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth. Dev Cell. 2016 May 23;37(4):362-376. [Content Brief]

[3]. Ching-Wen Chang, et al. CEP295 interacts with microtubules and is required for centriole elongation. J Cell Sci. 2016 Jul 1;129(13):2501-13. [Content Brief]

[4]. Xiangdong Zheng, et al. Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length. Nat Commun. 2016 Jun 16;7:11874. [Content Brief]

[5]. Chieh-Ju C Tang, et al. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. EMBO J. 2011 Oct 21;30(23):4790-804. [Content Brief]

[6]. Jaerak Chang, et al. PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle. EMBO J. 2010 Jul 21;29(14):2395-406. [Content Brief]

[7]. Liang-Yi Hung, et al. Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly. Mol Biol Cell. 2004 Jun;15(6):2697-706. [Content Brief]

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