cGMP-dependent 3',5'-cyclic phosphodiesterase
Definition:
References:
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[1]. Kenichi Hiramoto, et al. Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells. Cell Signal. 2014 Sep;26(9):1807-17. [Content Brief]
[2]. Vincenzo Salpietro, et al. A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea. Mov Disord. 2018 Mar;33(3):482-488. [Content Brief]
[3]. Stefania Monterisi, et al. PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling. Elife. 2017 May 2;6:e21374. [Content Brief]
[4]. G J Rosman, et al. Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase. Gene. 1997 May 20;191(1):89-95. [Content Brief]
[5]. André Iffland, et al. Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. Biochemistry. 2005 Jun 14;44(23):8312-25. [Content Brief]
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