cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Definition:
References:
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[1]. Stefan Berrisch, et al. cUMP hydrolysis by PDE3A. Naunyn Schmiedebergs Arch Pharmacol. 2017 Mar;390(3):269-280. [Content Brief]
[2]. Philipp G Maass, et al. PDE3A mutations cause autosomal dominant hypertension with brachydactyly. Nat Genet. 2015 Jun;47(6):647-53. [Content Brief]
[3]. Dianrong Li, et al. Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover. Mol Cell. 2019 Sep 19;75(6):1103-1116.e9. [Content Brief]
[4]. E Meacci, et al. Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3721-5. [Content Brief]
[5]. Jie Chen, et al. Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. Nat Commun. 2021 Oct 27;12(1):6204. [Content Brief]
[6]. P P Cheung, et al. Human platelet cGI-PDE: expression in yeast and localization of the catalytic domain by deletion mutagenesis. Blood. 1996 Aug 15;88(4):1321-9. [Content Brief]
[7]. E Degerman, et al. Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase. Biochim Biophys Acta. 1994 Apr 13;1205(2):189-98. [Content Brief]
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