Chloride intracellular channel protein 2

Definition:

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.

References:

[1]. Brett A Cromer, et al. Structure of the Janus protein human CLIC2. J Mol Biol. 2007 Nov 30;374(3):719-31. [Content Brief]

[2]. Philip G Board, et al. CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels. Int J Biochem Cell Biol. 2004 Aug;36(8):1599-612. [Content Brief]

[3]. Angela F Dulhunty, et al. A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP. Biochem J. 2005 Aug 15;390(Pt 1):333-43. [Content Brief]

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