Chromodomain-helicase-DNA-binding protein 1-like

Definition:

ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin.

References:

[1]. Jugal Mohapatra, et al. Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. Elife. 2021 Dec 7;10:e71502. [Content Brief]

[2]. Luka Bacic, et al. Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome. Elife. 2021 Sep 6;10:e71420. [Content Brief]

[3]. Laura C Lehmann, et al. Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1. Mol Cell. 2017 Dec 7;68(5):847-859.e7. [Content Brief]

[4]. Li Wang, et al. Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. Nat Commun. 2021 Jul 1;12(1):4057. [Content Brief]

[5]. Hari R Singh, et al. A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene. Mol Cell. 2017 Dec 7;68(5):860-871.e7. [Content Brief]

[6]. Dragana Ahel, et al. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science. 2009 Sep 4;325(5945):1240-3. [Content Brief]

[7]. Laura C Lehmann, et al. Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch. Cell Rep. 2020 Dec 22;33(12):108529. [Content Brief]

[8]. Charlotte Blessing, et al. The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks. Mol Cell. 2020 Dec 3;80(5):862-875.e6. [Content Brief]

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