Chymotrypsin-like elastase family member 2A

Definition:

Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.

References:

[1]. Fatemehsadat Esteghamat, et al. CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. Nat Genet. 2019 Aug;51(8):1233-1243. [Content Brief]

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