Cilium assembly protein DZIP1L

Definition:

Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane.

References:

[1]. Andrew M Glazer, et al. The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. Dev Biol. 2010 Jan 1;337(1):148-56. [Content Brief]

[2]. Hao Lu, et al. Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Nat Genet. 2017 Jul;49(7):1025-1034. [Content Brief]

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