CINCA syndrome

Definition:

Chronic infantile neurological cutaneous and articular (CINCA) syndrome, also known as neonatal onset multisystemic inflammatory disease (NOMID), is a rare congenital inflammatory disorder characterized by neonatal onset of cutaneous symptoms, chronic meningitis, and joint manifestations with recurrent fever and inflammation. It represents the most severe phenotype of the cryopyrin-associated periodic syndrome (CAPS).

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