Clathrin heavy chain 1

Definition:

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation.

References:

[1]. Stephen J Royle, et al. Clathrin is required for the function of the mitotic spindle. Nature. 2005 Apr 28;434(7037):1152-7. [Content Brief]

[2]. Brinda Ravikumar, et al. Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol. 2010 Aug;12(8):747-57. [Content Brief]

[3]. Stephen J Royle, et al. Trimerisation is important for the function of clathrin at the mitotic spindle. J Cell Sci. 2006 Oct 1;119(Pt 19):4071-8. [Content Brief]

[4]. Daniel G Booth, et al. A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO J. 2011 Mar 2;30(5):906-19. [Content Brief]

[5]. Liam P Cheeseman, et al. Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. J Cell Sci. 2013 May 1;126(Pt 9):2102-13. [Content Brief]

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