CMP-sialic acid transporter

Definition:

Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (By similarity). Also mediates the transport of CDP-ribitol (By similarity).

References:

[1]. Miski Mohamed, et al. Intellectual disability and bleeding diathesis due to deficient CMP--sialic acid transport. Neurology. 2013 Aug 13;81(7):681-7. [Content Brief]

[2]. Ivan Martinez-Duncker, et al. Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter. Blood. 2005 Apr 1;105(7):2671-6. [Content Brief]

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