Condensin complex subunit 2
Definition:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
References:
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[1]. K Kimura, et al. Chromosome condensation by a human condensin complex in Xenopus egg extracts. J Biol Chem. 2001 Feb 23;276(8):5417-20. [Content Brief]
[2]. Carol-Anne Martin, et al. Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis. Genes Dev. 2016 Oct 1;30(19):2158-2172. [Content Brief]
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