Copine-1

Definition:

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.

References:

[1]. C S Ramsey, et al. Copine-I represses NF-kappaB transcription by endoproteolysis of p65. Oncogene. 2008 Jun 5;27(25):3516-26. [Content Brief]

[2]. Nammi Park, et al. Copine1 enhances neuronal differentiation of the hippocampal progenitor HiB5 cells. Mol Cells. 2012 Dec;34(6):549-54. [Content Brief]

[3]. Jose Luis Tomsig, et al. Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine. Biochem J. 2004 Mar 15;378(Pt 3):1089-94. [Content Brief]

[4]. C E Creutz, et al. The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. J Biol Chem. 1998 Jan 16;273(3):1393-402. [Content Brief]

[5]. Carl E Creutz, et al. Organization and synergistic binding of copine I and annexin A1 on supported lipid bilayers observed by atomic force microscopy. Biochim Biophys Acta. 2009 Sep;1788(9):1950-61. [Content Brief]

[6]. Nammi Park, et al. Copine1 C2 domains have a critical calcium-independent role in the neuronal differentiation of hippocampal progenitor HiB5 cells. Biochem Biophys Res Commun. 2014 Nov 7;454(1):228-33. [Content Brief]

[7]. Jose Luis Tomsig, et al. Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. J Biol Chem. 2003 Mar 21;278(12):10048-54. [Content Brief]

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