Corepressor interacting with RBPJ 1

Definition:

May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.

References:

[1]. Anthony G Pajerowski, et al. NKAP is a transcriptional repressor of notch signaling and is required for T cell development. Immunity. 2009 May;30(5):696-707. [Content Brief]

[2]. J J Hsieh, et al. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):23-8. [Content Brief]

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