Cyclin-dependent kinase 20

Definition:

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.

References:

[1]. Yu Liu, et al. p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. J Biol Chem. 2004 Feb 6;279(6):4507-14. [Content Brief]

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