Cyclin-dependent kinase-like 5

Definition:

Mediates phosphorylation of MECP2. May regulate ciliogenesis.

References:

[1]. Peter Canning, et al. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep. 2018 Jan 23;22(4):885-894. [Content Brief]

[2]. Ilaria Bertani, et al. Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation. J Biol Chem. 2006 Oct 20;281(42):32048-56. [Content Brief]

[3]. Francesca Mari, et al. CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome. Hum Mol Genet. 2005 Jul 15;14(14):1935-46. [Content Brief]

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