Cysteine-rich motor neuron 1 protein

Definition:

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.

References:

[1]. Jens Glienke, et al. CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo. Mech Dev. 2002 Dec;119(2):165-75. [Content Brief]

[2]. Lorine Wilkinson, et al. CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. J Biol Chem. 2003 Sep 5;278(36):34181-8. [Content Brief]

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