Degrader

Definition:

Degrader is a compound that result in loss of both enzymatic and non-enzymatic functions of proteins, such as the scaffolding function of kinases or the gene regulatory functions of transcriptional effectors.

References:

[1]. Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10. [Content Brief]

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