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Detroit 562

Definition:

Detroit 562 is a human cancer cell line derived from Pleural effusion and associated with Pharyngeal squamous cell carcinoma and Squamous cell carcinoma of the oral cavity. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. Detroit 562 is used as an in vitro model of Pharyngeal squamous cell carcinoma and Squamous cell carcinoma of the oral cavity to investigate cell invasion.

References:

[1]. Kibble EA, et al. The Detroit 562 Pharyngeal Immortalized Cell Line Model for the Assessment of Infectivity of Pathogenic Neisseria sp. Methods in molecular biology (Clifton, N.J.). 2019;1969:123-133.

[2]. Bergmann S, Schoenen H, Hammerschmidt S. The interaction between bacterial enolase and plasminogen promotes adherence of Streptococcus pneumoniae to epithelial and endothelial cells. International journal of medical microbiology : IJMM. 2013;303(8):452-62.

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