E3 SUMO-protein ligase ZNF451

Definition:

E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.

References:

[1]. Ulla Karvonen, et al. ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. J Mol Biol. 2008 Oct 10;382(3):585-600. [Content Brief]

[2]. Laurent Cappadocia, et al. Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase. Nat Struct Mol Biol. 2015 Dec;22(12):968-75. [Content Brief]

[3]. Nathalie Eisenhardt, et al. A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly. Nat Struct Mol Biol. 2015 Dec;22(12):959-67. [Content Brief]

[4]. Yili Feng, et al. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling. J Biol Chem. 2014 Jan 24;289(4):2072-83. [Content Brief]

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