E3 ubiquitin-protein ligase MARCHF8

Definition:

E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

References:

[1]. Nicolas Lapaque, et al. The HLA-DRalpha chain is modified by polyubiquitination. J Biol Chem. 2009 Mar 13;284(11):7007-16. [Content Brief]

[2]. Marie-Elaine Gauvreau, et al. Sorting of MHC class II molecules into exosomes through a ubiquitin-independent pathway. Traffic. 2009 Oct;10(10):1518-27. [Content Brief]

[3]. Jacques Thibodeau, et al. Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. Eur J Immunol. 2008 May;38(5):1225-30. [Content Brief]

[4]. Eric Bartee, et al. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol. 2004 Feb;78(3):1109-20. [Content Brief]

[5]. Eiji Goto, et al. c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. J Biol Chem. 2003 Apr 25;278(17):14657-68. [Content Brief]

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