E3 ubiquitin-protein ligase RNF183
Definition:
Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling.
References:
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[1]. Yanfang Wu, et al. Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2762-E2771. [Content Brief]
[2]. Kimberly E Maxfield, et al. Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. Nat Commun. 2015 Nov 16;6:8840. [Content Brief]
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