E3 ubiquitin-protein ligase TRIM37

Definition:

E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome. Has anti-HIV activity.

References:

[1]. Azah A Tabah, et al. Anti-HIV-1 activity of Trim 37. J Gen Virol. 2014 Apr;95(Pt 4):960-967. [Content Brief]

[2]. Wei Wang, et al. TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import. J Cell Biol. 2017 Sep 4;216(9):2843-2858. [Content Brief]

[3]. Sanchita Bhatnagar, et al. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature. 2014 Dec 4;516(7529):116-20. [Content Brief]

[4]. Jukka Kallijärvi, et al. TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase. Exp Cell Res. 2005 Aug 1;308(1):146-55. [Content Brief]

[5]. Fernando R Balestra, et al. Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells. Dev Cell. 2013 Jun 24;25(6):555-71. [Content Brief]

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