2. Biology Dictionary
  3. E3 ubiquitin-protein ligase TRIM58

E3 ubiquitin-protein ligase TRIM58

Definition:

E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.

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