E3 ubiquitin-protein ligase TTC3
Definition:
References:
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[1]. Futoshi Suizu, et al. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell. 2009 Dec;17(6):800-10. [Content Brief]
[2]. Yueqing Gong, et al. Overexpressed TTC3 Protein Tends to be Cleaved into Fragments and Form Aggregates in the Nucleus. Neuromolecular Med. 2019 Mar;21(1):85-96. [Content Brief]
[3]. Gaia Berto, et al. The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase. J Cell Sci. 2007 Jun 1;120(Pt 11):1859-67. [Content Brief]
[4]. Gaia Elena Berto, et al. The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways. PLoS One. 2014 Apr 2;9(4):e93721. [Content Brief]
[5]. June-Hyung Kim, et al. TTC3 contributes to TGF-β1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation. Cell Death Dis. 2019 Jan 29;10(2):92. [Content Brief]
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