Echinoderm microtubule-associated protein-like 3

Definition:

Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation. Required for proper alignnment of chromosomes during metaphase.

References:

[1]. Justus Tegha-Dunghu, et al. EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase. J Cell Sci. 2008 May 15;121(Pt 10):1718-26. [Content Brief]

[2]. Jia Luo, et al. The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules. J Biol Chem. 2019 Apr 5;294(14):5643-5656. [Content Brief]

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