eIF5-mimic protein 2

Definition:

Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function. Enhances histone H4 gene transcription but does not seem to bind DNA directly.

References:

[1]. Gary Loughran, et al. Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection. PLoS One. 2018 Feb 22;13(2):e0192648. [Content Brief]

[2]. Chingakham Ranjit Singh, et al. Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism. Cell Rep. 2021 Jul 13;36(2):109376. [Content Brief]

[3]. P Mitra, et al. Purification and functional analysis of a novel leucine-zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription. Biochemistry. 2001 Sep 4;40(35):10693-9. [Content Brief]

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