Growth/differentiation factor 5
Definition:
References:
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[1]. K Triantafilou, et al. A CD14-independent LPS receptor cluster. Nat Immunol. 2001 Apr;2(4):338-45. [Content Brief]
[2]. Elisa Degenkolbe, et al. A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. PLoS Genet. 2013;9(10):e1003846. [Content Brief]
[3]. Petra Seemann, et al. Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN. PLoS Genet. 2009 Nov;5(11):e1000747. [Content Brief]
[4]. Alexander Kotzsch, et al. Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. EMBO J. 2009 Apr 8;28(7):937-47. [Content Brief]
[5]. Xiaowen Bai, et al. Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes. Biochem Biophys Res Commun. 2004 Dec 10;325(2):453-60. [Content Brief]
[6]. Katja Stange, et al. Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C. J Mol Biol. 2014 Sep 23;426(19):3221-3231. [Content Brief]
[7]. Gerburg K Schwaerzer, et al. New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. J Bone Miner Res. 2012 Feb;27(2):429-42. [Content Brief]
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