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HCT-116/VM46

Definition:

HCT-116/VM46 is a human cancer cell line derived from Colon and associated with Colon carcinoma. HCT-116/VM46 is a resistant derivative of HCT 116 selected against Teniposide (VM-26. HCT-116/VM46 is used as an in vitro model of Colon carcinoma to investigate tumor-cell growth, cell survival, and pharmacological response.

Références:

[1]. Wang L, et al. Reversal of the human and murine multidrug-resistance phenotype with megestrol acetate. Cancer chemotherapy and pharmacology. 1994;34(2):96-102.

[2]. Radakovic A, Boger DL. High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs. Bioorganic & medicinal chemistry letters. 2018;28(5):863-865. [Content Brief]

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