Hepatitis B

Definition:

Hepatitis B is an infectious disease caused by hepatitis B virus (HBV) belonging to the Hepadnaviridae family of dsDNA-RT viruses. Both acute and chronic hepatitis B can be caused by blood-borne HBV infections. The risk of developing chronic hepatitis B is directly related to the age of first infection, much higher for infants. Chronic hepatitis B may eventaully lead to cirrhosis and hepatocellular carcinoma.

References:

[1]. Angela J Frodsham, et al. Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9148-53. [Content Brief]

[2]. Chutima Pramoolsinsup, et al. Management of viral hepatitis B. J Gastroenterol Hepatol. 2002 Feb;17 Suppl:S125-45. [Content Brief]

[3]. G Nebbia, et al. Hepatitis B infection: current concepts and future challenges. QJM. 2012 Feb;105(2):109-13. [Content Brief]

[4]. Jie Zhou, et al. A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection. Immunogenetics. 2009 Jun;61(6):423-30. [Content Brief]

[5]. Ya-Jun Tan, et al. Hepatitis B virus infection and the risk of hepatocellular carcinoma. World J Gastroenterol. 2011 Nov 28;17(44):4853-7. [Content Brief]

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