Hexokinase-2
Definition:
References:
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[1]. Hong Lin, et al. Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. ACS Med Chem Lett. 2015 Dec 28;7(3):217-22. [Content Brief]
[2]. Eric C Cheung, et al. Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20491-6. [Content Brief]
[3]. Federica Chiara, et al. Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS One. 2008 Mar 19;3(3):e1852. [Content Brief]
[4]. Mir Hussain Nawaz, et al. The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation. Biosci Rep. 2018 Feb 21;38(1):BSR20171666. [Content Brief]
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