Histone deacetylase complex subunit SAP30

Definition

Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.; (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC.

References:

[1]. Jie Chen, et al. Transcriptional regulation by HSV-1 induced HTRP via acetylation system. Virol Sin. 2010 Dec;25(6):417-24. [Content Brief]

[2]. Y Zhang, et al. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell. 1998 Jun;1(7):1021-31. [Content Brief]

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