Histone deacetylase (HDAC)
Definition:
Histone deacetylase (HDAC) is a major class of deacetylation enzymes. HDAC catalyzes the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. Many HDACs exist in large protein complexes in cells and their functions strongly depend on the complex composition.
References:
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[1]. Edward Seto, et al. Erasers of histone acetylation: the histone deacetylase enzymes. Cold Spring Harb Perspect Biol. 2014 Apr 1;6(4):a018713. [Content Brief]
[2]. Jianfu Zhang, et al. Identification of Histone deacetylase (HDAC)-Associated Proteins with DNA-Programmed Affinity Labeling. Angew Chem Int Ed Engl. 2020 Sep 28;59(40):17525-17532. [Content Brief]
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